Communication Between DNA Damage and Immune Responses
24th March 2021 at 15:00 – 16:00 GMT
Hosted by Dr Simon Boulton, Group Leader at the Crick and Radiation Resistance Theme Lead, we will be exploring communication between DNA damage and immune responses with guest speaker, Professor Roger Greenberg, University of Pennsylvania.
A bit about our speaker:
Professor Roger Greenberg investigates basic mechanisms of DNA repair that impact cancer etiology and response to therapy.
His major research interests center on (1) the molecular basis of DNA double-strand break recognition and repair by the breast cancer suppressor proteins BRCA1 and BRCA2, and (2) noncanonical DNA repair mechanisms that become exaggerated in cancers harboring BRCA mutations and in those that rely on alternative telomere maintenance. He has developed novel methodologies at the single-cell and molecule levels to visualize all major steps of homologous recombination in real-time, discovered chromatin mechanisms that are responsible for responses to PARP inhibition, and showed that inherited biallelic BRCA1 mutations are causative for Fanconi Anemia.
Recently, his investigations have expanded to communication between DNA damage and immune responses. This revealed that mitotic progression following DNA damage enables pattern recognition of missegregated DNA in the cytoplasm to drive inflammatory stimulated gene expression that elicits anti-tumor immune responses.
To join this exciting seminar, please register here and a Zoom call link will be sent to you.
We look forward to seeing you there.